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John Agar (Dr. Matt Hastings)
Mara Corday (Stephanie 'Steve' Clayton)
Leo G. Carroll (Prof. Gerald Deemer)
Nestor Paiva (Sheriff Jack Andrews)
Ross Elliott (Joe Burch)
Edwin Rand (Lt. John Nolan)
A spider escapes from an isolated desert laboratory experimenting in giantism and grows to tremendous size as it wreaks havoc on the local inhabitants.
The 1952 Cessna 170B, N8157A, that appears in the film is still operational in Los Angeles County.